Expertise
Antibody and protein design
- Humanization
- Affinity maturation and reduction
- Stabilization
- Format design (bispecifics, scFv, linkers, sdAb a.k.a. VHH a.k.a. nanobody)
- Library design
Structure prediction and modeling
- ML structure prediction
- Rotamers and energy functions
- Patch analysis for developability (hydrophobic, charged)
Sequence analysis
- PTMs and sequence liabilities
- Somatic hypermutation
- Flagging unusual residues
- Database, literature and patent search
- In silico immunogenicity prediction and redesign
Custom workflows and coding